Chromenone 1

Modify Date: 2025-08-25 12:03:59

Chromenone 1 Structure
Chromenone 1 structure
Common Name Chromenone 1
CAS Number 1639929-29-5 Molecular Weight 357.29
Density N/A Boiling Point N/A
Molecular Formula C18H10F3N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Chromenone 1


Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs[1].

 Names

Name Chromenone 1

 Chromenone 1 Biological Activity

Description Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs[1].
Related Catalog
In Vitro Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts[1].
References

[1]. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990.

 Chemical & Physical Properties

Molecular Formula C18H10F3N3O2
Molecular Weight 357.29
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