Chromenone 1

Names

[ Name ]:
Chromenone 1

Biological Activity

[Description]:

Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs[1].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts[1].

[References]

[1]. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₀F₃N₃O₂

[ Molecular Weight ]:
357.29

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.