Fluoroethylnormemantine hydrochloride
Modify Date: 2024-01-09 11:09:56
Fluoroethylnormemantine hydrochloride structure
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Common Name | Fluoroethylnormemantine hydrochloride | ||
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| CAS Number | 1639210-25-5 | Molecular Weight | 233.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H21ClFN | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Fluoroethylnormemantine hydrochlorideFluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3]. |
| Name | Fluoroethylnormemantine hydrochloride |
|---|
| Description | Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3]. |
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| Related Catalog | |
| Target |
NMDA receptor[1] |
| In Vivo | Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35-induced learning impairments in mice[1]. Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1]. Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2]. Animal Model: Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1] Dosage: 0.1, 0.3, 1, 3, 10 mg/kg Administration: I.p. 30 minutes before the behavioral tests Result: Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit. |
| References |
| Molecular Formula | C12H21ClFN |
|---|---|
| Molecular Weight | 233.75 |