DETQ
Modify Date: 2024-09-11 16:58:56
DETQ structure
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Common Name | DETQ | ||
|---|---|---|---|---|
| CAS Number | 1638667-81-8 | Molecular Weight | 422.346 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25Cl2NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DETQA novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM; induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor; robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine. |
| Name | DETQ |
|---|
| Description | A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM; induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor; robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine. |
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| References | References 1. Svensson KA, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128. 2. Bruns RF, et al. Neuropharmacology. 2018 Jan;128:351-365. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C22H25Cl2NO3 |
|---|---|
| Molecular Weight | 422.346 |