DETQ

A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM; induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor; robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine.

References 1. Svensson KA, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128. 2. Bruns RF, et al. Neuropharmacology. 2018 Jan;128:351-365. View Related Products by Target Dopamine Receptor