1638667-81-8
1638667-81-8 structure
- Name: DETQ
- Chemical Name: DETQ
- CAS Number: 1638667-81-8
- Molecular Formula: C22H25Cl2NO3
- Molecular Weight: 422.346
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2020-01-19 20:06:57
- Modify Date: 2024-09-11 16:58:56
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A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM; induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor; robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine.
| Name | DETQ |
|---|
| Description | A novel potent, selective, allosteric and orally active dopamine D1 receptor potentiator with Kb of 26 nM; induces a 21-fold leftward shift in the cAMP response to dopamine in HEK293 cells, 30-fold less potent at rat and mouse D1 receptors and is inactive at the human D5 receptor; robustly (∼10-fold) increases locomotor activity in habituated hD1 mice (3-20 mg/kg), also acts synergistically with L-DOPA to reverse the strong hypokinesia caused by reserpine. |
|---|---|
| References | References 1. Svensson KA, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128. 2. Bruns RF, et al. Neuropharmacology. 2018 Jan;128:351-365. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C22H25Cl2NO3 |
|---|---|
| Molecular Weight | 422.346 |