Pazufloxacin mesylate

Modify Date: 2024-01-02 22:15:35

Pazufloxacin mesylate Structure
Pazufloxacin mesylate structure
 Common Name Pazufloxacin mesylate
CAS Number 163680-77-1 Molecular Weight 414.405
Density N/A Boiling Point 531.5ºC at 760 mmHg
Molecular Formula C17H19FN2O7S Melting Point >255°C (dec.)
MSDS Chinese USA Flash Point 275.2ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Pazufloxacin mesylate


Pazufloxacin (T-3761) mesylate is a fluoroquinolone antibiotic.Target: AntibacterialPazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus [1]. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively [2].

 Names

Name Pazufloxacin Mesylate
Synonym More Synonyms

 Pazufloxacin mesylate Biological Activity

Description Pazufloxacin (T-3761) mesylate is a fluoroquinolone antibiotic.Target: AntibacterialPazufloxacin (T-3761), a new quinolone derivative, showed broad and potent antibacterial activity. T-3761 showed good efficacy in mice against systemic, pulmonary, and urinary tract infections with gram-positive and gram-negative bacteria, including quinolone-resistant Serratia marcescens and Pseudomonas aeruginosa. The in vivo activity of T-3761 was comparable to or greater than those of ofloxacin, ciprofloxacin, norfloxacin, and tosufloxacin against most infection models in mice. The activities of T-3761 were lower than those of tosufloxacin against gram-positive bacterial systemic and pulmonary infections in mice but not against infections with methicillin-resistant Staphylococcus aureus [1]. T-3761 had a broad spectrum of activity and had potent activity against gram-positive and -negative bacteria. The MICs of T-3761 against 90% of the methicillin-susceptible Staphylococcus aureus, methicillin-susceptible and -resistant Staphylococcus epidermidis, and Clostridium spp. tested were 0.39 to 6.25 micrograms/ml. The MBCs of T-3761 were either equal to or twofold greater than the MICs. The 50% inhibitory concentrations of T-3761 for DNA gyrases isolated from E. coli and P. aeruginosa were 0.88 and 1.9 micrograms/ml, respectively [2].
Related Catalog
References

[1]. Fukuoka, Y., et al., In vitro and in vivo antibacterial activities of T-3761, a new quinolone derivative. Antimicrob Agents Chemother, 1993. 37(3): p. 384-92.

[2]. Muratani, T., M. Inoue, and S. Mitsuhashi, In vitro activity of T-3761, a new fluoroquinolone. Antimicrob Agents Chemother, 1992. 36(10): p. 2293-303.

 Chemical & Physical Properties

Boiling Point 531.5ºC at 760 mmHg
Melting Point >255°C (dec.)
Molecular Formula C17H19FN2O7S
Molecular Weight 414.405
Flash Point 275.2ºC
Exact Mass 414.089691
PSA 157.30000
LogP 3.02510
Vapour Pressure 4E-12mmHg at 25°C
Storage condition -20°C Freezer

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;C: Corrosive;F: Flammable;
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
RTECS UU8815400

 Synonyms

Pazufloxacin mesylate
(3S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate (1:1)
MFCD00913262
(3S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
Pazufloxacin Methanesulfonate
7H-1,4-Oxazino[2,3,4-ij]quinoline-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3R)-, methanesulfonate (1:1)
7H-1,4-Oxazino[2,3,4-ij]quinoline-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
(3R)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate (1:1)
Pazufloxacin mesilate
Pazufloxacin (mesylate)
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127046-45-1
Pazufloxacin
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pazufloxacin
166665-94-7
Pazufloxacin
127045-37-8
Pazufloxacin-d4
1346602-96-7
ent-Pazufloxacin-d4 mesylate
1346602-24-1
Chemsrc provides Pazufloxacin mesylate(CAS#:163680-77-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Pazufloxacin mesylate are included as well.>> amp version: Pazufloxacin mesylate

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