antcin A

Modify Date: 2024-01-02 15:31:27

antcin A structure	Common Name	antcin A
	CAS Number	163597-24-8	Molecular Weight	454.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₄₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of antcin A

Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].

Name	(2S,6R)-2-methyl-3-methylidene-6-[(4S,5S,10S,13R,14R,17R)-4,10,13-trimethyl-3,11-dioxo-2,4,5,6,7,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]heptanoic acid
Synonym	More Synonyms

Description	Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3[1].
References	[1]. Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.

Molecular Formula	C₂₉H₄₂O₄
Molecular Weight	454.64
Exact Mass	454.30800
PSA	71.44000
LogP	6.39680

(4alpha,5alpha,25S)-4-Methyl-3,11-dioxoergosta-8,24(28)-dien-26-oic acid

anticin A

Ergosta-8,24(28)-dien-26-oicacid,4-methyl-3,11-dioxo-,(4a,5a,25S)

AntcinA

antcin A

Use of antcin A

Names

antcin A Biological Activity

Chemical & Physical Properties

Synonyms