163597-24-8

163597-24-8 structure

Name: antcin A
Chemical Name: (2S,6R)-2-methyl-3-methylidene-6-[(4S,5S,10S,13R,14R,17R)-4,10,13-trimethyl-3,11-dioxo-2,4,5,6,7,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]heptanoic acid
CAS Number: 163597-24-8
Molecular Formula: C₂₉H₄₂O₄
Molecular Weight: 454.64
Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
Create Date: 2017-03-05 13:07:34
Modify Date: 2025-08-25 20:41:08
Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].

Name	(2S,6R)-2-methyl-3-methylidene-6-[(4S,5S,10S,13R,14R,17R)-4,10,13-trimethyl-3,11-dioxo-2,4,5,6,7,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]heptanoic acid
Synonyms	(4alpha,5alpha,25S)-4-Methyl-3,11-dioxoergosta-8,24(28)-dien-26-oic acid anticin A Ergosta-8,24(28)-dien-26-oicacid,4-methyl-3,11-dioxo-,(4a,5a,25S) AntcinA

Description	Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NLRP3[1].
References	[1]. Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.