antcin A

Names

[ Name ]:
antcin A

[Synonym ]:
(4alpha,5alpha,25S)-4-Methyl-3,11-dioxoergosta-8,24(28)-dien-26-oic acid
anticin A
Ergosta-8,24(28)-dien-26-oicacid,4-methyl-3,11-dioxo-,(4a,5a,25S)
AntcinA

Biological Activity

[Description]:

Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)

Research Areas >> Inflammation/Immunology

[Target]

NLRP3[1].

[References]

[1]. Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₄₂O₄

[ Molecular Weight ]:
454.64

[ Exact Mass ]:
454.30800

[ PSA ]:
71.44000

[ LogP ]:
6.39680

Related Compounds

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