Teriflunomide
Modify Date: 2024-01-02 06:58:13
Teriflunomide structure
|
Common Name | Teriflunomide | ||
|---|---|---|---|---|
| CAS Number | 163451-81-8 | Molecular Weight | 270.207 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 410.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H9F3N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 202.3±28.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of TeriflunomideTeriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation. |
| Name | teriflunomide |
|---|---|
| Synonym | More Synonyms |
| Description | Teriflunomide is the active metabolite of leflunomide, an approved therapy for rheumatoid arthritis. It inhibits pyrimidine synthesis and therefore potently decreases T cell and B cell proliferation. |
|---|---|
| Related Catalog | |
| In Vitro | Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes[1]. |
| In Vivo | Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 410.8±45.0 °C at 760 mmHg |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.207 |
| Flash Point | 202.3±28.7 °C |
| Exact Mass | 270.061615 |
| PSA | 73.12000 |
| LogP | 2.51 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Storage condition | -20°C |
| HS Code | 2942000000 |
|---|
| (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide |
| Aubagio |
| (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide |
| (Z)-2-Cyano-3-hydroxy-but-2-enoic acid (4-trifluoromethyl-phenyl)-amide |
| 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-, (2Z)- |
| (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide |
| Teriflunomide |
| (Z)-2-Cyano-a',a',a'-trifluoro-3-hydroxy-p-crotonotoluidide |
| A771726 |
| Leflunomide Impurity 2 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Teriflunomide
- Price: ￥1818.0/250mg ￥648.0/50mg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Teriflunomide(A-771726)
- Price: $500.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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Price: ￥273/10mg
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