Malaoxon

Modify Date: 2024-01-11 18:15:17

Malaoxon structure	Common Name	Malaoxon
	CAS Number	1634-78-2	Molecular Weight	314.292
	Density	1.2±0.1 g/cm3	Boiling Point	376.0±52.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₉O₇PS	Melting Point	<20℃
	MSDS	Chinese USA	Flash Point	181.2±30.7 °C
	Symbol	GHS06	Signal Word	Danger

Use of Malaoxon

Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity[1].

Name	diethyl 2-dimethoxyphosphorylsulfanylbutanedioate
Synonym	More Synonyms

Description	Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Angelini DJ, et al. The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells. Int J Toxicol. 2015 Sep-Oct;34(5):433-41.

Density	1.2±0.1 g/cm3
Boiling Point	376.0±52.0 °C at 760 mmHg
Melting Point	<20℃
Molecular Formula	C₁₀H₁₉O₇PS
Molecular Weight	314.292
Flash Point	181.2±30.7 °C
Exact Mass	314.058899
PSA	123.24000
LogP	2.07
Appearance of Characters	liquid
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.470

Malaoxon MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM8410000

CHEMICAL NAME :: Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorothioate

CAS REGISTRY NUMBER :: 1634-78-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H19-O7-P-S

MOLECULAR WEIGHT :: 314.32

WISWESSER LINE NOTATION :: 2OV1YVO2&SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 8200 ug/kg

SEX/DURATION :: female 18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 8,939,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H310
Precautionary Statements	Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P361 + P364
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	F,Xn,N,T
Risk Phrases	11-38-50/53-65-67-24/25
Safety Phrases	60-61-62-45-36/37/39-46-37-24
RIDADR	UN 3018
RTECS	WM8410000
Packaging Group	III
Hazard Class	6.1(b)

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Precursor 3
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DownStream 0

Acetylcholinesterase immobilized on magnetic beads for pesticides detection: application to olive oil analysis.

Sensors (Basel.) 12(6) , 7893-904, (2012)

This work presents the development of bioassays and biosensors for the detection of insecticides widely used in the treatment of olive trees. The systems are based on the covalent immobilisation of ac...

Risk assessment of pesticides detected in surface water of the Alqueva reservoir (Guadiana basin, southern of Portugal).

Sci. Total Environ. 488-489 , 208-19, (2014)

The purpose of this study was to evaluate the potential impact of the pesticides detected in the Alqueva reservoir (Guadiana Basin, South Iberian Peninsula) on the aquatic organisms belonging to this ...

Albumin binding as a potential biomarker of exposure to moderately low levels of organophosphorus pesticides.

Biol. Cell 13 , 343-63, (2008)

We have evaluated the potential of plasma albumin to provide a sensitive biomarker of exposure to commonly used organophosphorus pesticides in order to complement the widely used measure of acetylchol...

diethyl 2-[(dimethoxyphosphoryl)thio]succinate

Malathion impurity B

Liromat

Diethyl-2-[(dimethoxyphosphoryl)sulfanyl]butandioat

Malathion-O-analog

dimethoxyphosphorylsulfanyl-succinic acid diethyl ester

Maloxon

rac-malaoxon

diethyl 2-[(dimethoxyphosphoryl)sulfanyl]butanedioate

Diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate

Butanedioic acid, 2-[(dimethoxyphosphinyl)thio]-, diethyl ester

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MFCD00055461

Butanedioic acid, [(dimethoxyphosphinyl)thio]-, diethyl ester

Malaoxone

Oxycarbophos

Carbethoxy malaoxon

Malaoxon

DC Chemicals Limited
China
Product Name: Malaoxon
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Purity: 98.0%
Stocking Period: 3 Day
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Malaoxon

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Malaoxon Biological Activity

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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