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Malaoxon

Names

[ CAS No. ]:
1634-78-2

[ Name ]:
Malaoxon

[Synonym ]:
diethyl 2-[(dimethoxyphosphoryl)thio]succinate
Malathion impurity B
Liromat
Diethyl-2-[(dimethoxyphosphoryl)sulfanyl]butandioat
Malathion-O-analog
dimethoxyphosphorylsulfanyl-succinic acid diethyl ester
Maloxon
rac-malaoxon
diethyl 2-[(dimethoxyphosphoryl)sulfanyl]butanedioate
Diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate
Butanedioic acid, 2-[(dimethoxyphosphinyl)thio]-, diethyl ester
Dimethoxyphosphorylmercapto-bernsteinsaeure-diaethylester
MFCD00055461
Butanedioic acid, [(dimethoxyphosphinyl)thio]-, diethyl ester
Malaoxone
Oxycarbophos
Carbethoxy malaoxon
Malaoxon

Biological Activity

[Description]:

Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Angelini DJ, et al. The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by Different Mechanisms in Cultured Human Pulmonary Cells. Int J Toxicol. 2015 Sep-Oct;34(5):433-41.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
376.0±52.0 °C at 760 mmHg

[ Melting Point ]:
<20℃

[ Molecular Formula ]:
C10H19O7PS

[ Molecular Weight ]:
314.292

[ Flash Point ]:
181.2±30.7 °C

[ Exact Mass ]:
314.058899

[ PSA ]:
123.24000

[ LogP ]:
2.07

[ Appearance of Characters ]:
liquid

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.470

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WM8410000
CHEMICAL NAME :
Succinic acid, mercapto-, diethyl ester, S-ester with O,O-dimethylphosphorothioate
CAS REGISTRY NUMBER :
1634-78-2
LAST UPDATED :
199806
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C10-H19-O7-P-S
MOLECULAR WEIGHT :
314.32
WISWESSER LINE NOTATION :
2OV1YVO2&SPO&O1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
158 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
215 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
8200 ug/kg
SEX/DURATION :
female 18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
100 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 8,939,1981

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H310

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P262-P280-P302 + P352 + P310-P361 + P364

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F,Xn,N,T

[ Risk Phrases ]:
11-38-50/53-65-67-24/25

[ Safety Phrases ]:
60-61-62-45-36/37/39-46-37-24

[ RIDADR ]:
UN 3018

[ RTECS ]:
WM8410000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Synthetic Route

Precursor & DownStream

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