DISODIUM FOLINATE
Modify Date: 2025-08-24 14:47:04
DISODIUM FOLINATE structure
|
Common Name | DISODIUM FOLINATE | ||
|---|---|---|---|---|
| CAS Number | 163254-40-8 | Molecular Weight | 517.403 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H21N7Na2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DISODIUM FOLINATEFolinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3]. |
| Name | UNII:4MXU9LJS4Q |
|---|---|
| Synonym | More Synonyms |
| Description | Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1]. |
| In Vivo | Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] Dosage: 7.0 mg/kg Administration: Intraperitoneal injection; every second day; for 3 weeks Result: Following MTX administration appears to reverse this growth inhibition. |
| References |
| Molecular Formula | C20H21N7Na2O7 |
|---|---|
| Molecular Weight | 517.403 |
| Exact Mass | 517.129761 |
| InChIKey | FSDMNNPYPVJNAT-RIWFDJIXSA-L |
| SMILES | Nc1nc2c(c(=O)[nH]1)N(C=O)C(CNc1ccc(C(=O)NC(CCC(=O)[O-])C(=O)[O-])cc1)CN2.[Na+].[Na+] |
| UNII:4MXU9LJS4Q |
| L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, sodium salt (1:2) |
| Disodium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate |
| MFCD11618008 |