DISODIUM FOLINATE

Names

[ Name ]:
DISODIUM FOLINATE

[Synonym ]:
UNII:4MXU9LJS4Q
L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, sodium salt (1:2)
Disodium (2S)-2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino}benzoyl)amino]pentanedioate
MFCD11618008

Biological Activity

[Description]:

Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate

[Target]

Human Endogenous Metabolite

[In Vitro]

Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1].

[In Vivo]

Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2]. Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] Dosage: 7.0 mg/kg Administration: Intraperitoneal injection; every second day; for 3 weeks Result: Following MTX administration appears to reverse this growth inhibition.

[References]

[1]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.

[2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.

[3]. Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₁N₇Na₂O₇

[ Molecular Weight ]:
517.403

[ Exact Mass ]:
517.129761

Related Compounds

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