IEM 1754 2HBr

Modify Date: 2025-08-25 21:33:34

IEM 1754 2HBr Structure
IEM 1754 2HBr structure
Common Name IEM 1754 2HBr
CAS Number 162831-31-4 Molecular Weight 412.25
Density N/A Boiling Point N/A
Molecular Formula C16H32Br2N2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IEM 1754 2HBr


IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].

 Names

Name 1,​5-​Pentanediamine, N1-​(tricyclo[3.3.1.13,​7]​dec-​1-​ylmethyl)​-​, hydrobromide
Synonym More Synonyms

 IEM 1754 2HBr Biological Activity

Description IEM-1754, a dicationic adamantane derivative, is a potent blocker of open channels of native ionotropic glutamate receptors including quisqualate-sensitive receptors in insect muscles, NMDAR in cultured rat cortical neurons, and AMPAR in freshly isolated hippocampal cells. IEM-1754 shows anticonvulsant potency in vivo[1][2].
Related Catalog
References

[1]. Tikhonov DB, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.

[2]. Lukomskaia NIa, et al. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian.

 Chemical & Physical Properties

Molecular Formula C16H32Br2N2
Molecular Weight 412.25
Exact Mass 410.093201
PSA 38.05000
LogP 4.97070
InChIKey JMPHTNNJCZDROM-UHFFFAOYSA-N
SMILES Br.Br.NCCCCCNCC12CC3CC(CC(C3)C1)C2
Storage condition -20℃

 Synonyms

1,5-Pentanediamine, N-(tricyclo[3.3.1.1]dec-1-ylmethyl)-, hydrobromide (1:2)
N-(Adamantan-1-ylmethyl)-1,5-pentanediamine dihydrobromide
IEM 1754 2HBr
IEM 1754 Dihydrobromide
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