KRFK
Modify Date: 2025-08-27 11:22:16
KRFK structure
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Common Name | KRFK | ||
|---|---|---|---|---|
| CAS Number | 162290-78-0 | Molecular Weight | 577.71900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H47N9O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRFKKRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach[1]. |
| Name | (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach[1]. |
|---|---|
| Related Catalog | |
| Target |
TGF-β[1] |
| In Vitro | KRFK (50 μm; 24 h) 激活 TGF-β 的分泌，降低 TSP-1 缺陷骨髓源性树突状细胞 (BMDCs) 中 DC 成熟标记物的表达[1]。 |
| In Vivo | KRFK (单只眼用药 5 μg/5 μL; 单剂量) 显著预防 TSP-1-/- 小鼠慢性眼表炎症的发生[1]。 |
| References |
| Molecular Formula | C27H47N9O5 |
|---|---|
| Molecular Weight | 577.71900 |
| Exact Mass | 577.37000 |
| PSA | 275.03000 |
| LogP | 4.42940 |
| InChIKey | WJJRVOBCSVZNET-CMOCDZPBSA-N |
| SMILES | NCCCCC(N)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCCN)C(=O)O |
| L-Lysine,L-lysyl-L-arginyl-L-phenylalanyl |