KRFK

Names

[ Name ]:
KRFK

[Synonym ]:
L-Lysine,L-lysyl-L-arginyl-L-phenylalanyl

Biological Activity

[Description]:

KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

TGF-β[1]

[In Vitro]

KRFK (50 μm; 24 h) 激活 TGF-β 的分泌，降低 TSP-1 缺陷骨髓源性树突状细胞 (BMDCs) 中 DC 成熟标记物的表达[1]。

[In Vivo]

KRFK (单只眼用药 5 μg/5 μL; 单剂量) 显著预防 TSP-1-/- 小鼠慢性眼表炎症的发生[1]。

[References]

[1]. Soriano-Romaní L, et al. Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018 Dec 20;20(1):9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₇N₉O₅

[ Molecular Weight ]:
577.71900

[ Exact Mass ]:
577.37000

[ PSA ]:
275.03000

[ LogP ]:
4.42940

Related Compounds

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