162290-78-0

162290-78-0 structure

Name: KRFK
Chemical Name: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid
CAS Number: 162290-78-0
Molecular Formula: C₂₇H₄₇N₉O₅
Molecular Weight: 577.71900
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-12-04 10:28:01
Modify Date: 2025-08-27 11:22:16
KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach[1].

Name	(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]hexanoic acid
Synonyms	L-Lysine,L-lysyl-L-arginyl-L-phenylalanyl

Description	KRFK, a peptide derived from TSP-1, can activate TGF-β. KRFK promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK can be used for chronic ocular surface inflammatory disorders reseach[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	TGF-β[1]
In Vitro	KRFK (50 μm; 24 h) 激活 TGF-β 的分泌，降低 TSP-1 缺陷骨髓源性树突状细胞 (BMDCs) 中 DC 成熟标记物的表达[1]。
In Vivo	KRFK (单只眼用药 5 μg/5 μL; 单剂量) 显著预防 TSP-1-/- 小鼠慢性眼表炎症的发生[1]。
References	[1]. Soriano-Romaní L, et al. Topical Application of TGF-β-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018 Dec 20;20(1):9.