RIPK1 inhibitor GS3145095
Modify Date: 2024-01-12 13:15:52
RIPK1 inhibitor GS3145095 structure
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Common Name | RIPK1 inhibitor GS3145095 | ||
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| CAS Number | 1622849-43-7 | Molecular Weight | 397.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H17F2N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RIPK1 inhibitor GS3145095GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1]. |
| Name | GSK3145095 |
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| Description | GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1]. |
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| Related Catalog | |
| Target |
IC50: 6.3 nM (RIP1 kinase )[1] |
| In Vitro | GSK3145095 potently blocks the TNF response as shown by determination of overall cell viability as measured by cellular ATP levels (IC50 = 1.6 nM), cell death as measured by LDH release (IC50 = 0.5 nM) and RIP1-dependent inflammatory cytokine MIP-1β production, either as absolute levels for protein, or fold changes in mRNA expression (IC50 = 0.4 nM) [1]. |
| References |
| Molecular Formula | C20H17F2N5O2 |
|---|---|
| Molecular Weight | 397.38 |