CI 1020

Modify Date: 2025-08-24 10:41:47

CI 1020 structure	Common Name	CI 1020
	CAS Number	162256-50-0	Molecular Weight	506.50
	Density	1.351g/cm3	Boiling Point	722.338ºC at 760 mmHg
	Molecular Formula	C₂₈H₂₆O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	242.505ºC

Use of CI 1020

CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration[1][2][3].

Name	3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]furan-2-one
Synonym	More Synonyms

Description	CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETA:0.3 nM (IC50)
References	[1]. Maguire JJ, et al. ETA receptor antagonists inhibit intimal smooth muscle cell proliferation in human vessels. Clin Sci (Lond). 2002 Aug;103 Suppl 48:184S-188S. [2]. Doherty AM, et al. Discovery and development of an endothelin A receptor-selective antagonist PD 156707. Pharm Biotechnol. 1998;11:81-112. [3]. Jones RD, et al. The effect of the endothelin ET(A) receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur J Pharmacol. 1999 Jun 25;374(3):367-75. [4]. Sheedy W, et al. The effect of the ETA receptor antagonist (CI-1020) in rats with established hypoxic pulmonary hypertension. Pulm Pharmacol Ther. 1998 Apr-Jun;11(2-3):173-6.

Density	1.351g/cm3
Boiling Point	722.338ºC at 760 mmHg
Molecular Formula	C₂₈H₂₆O₉
Molecular Weight	506.50
Flash Point	242.505ºC
Exact Mass	506.15800
PSA	101.91000
LogP	3.84810
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.623

2-(1,3-benzodio...

CAS#:162256-48-6

CI 1020

CAS#:162256-50-0

Literature: Journal of Medicinal Chemistry, , vol. 42, # 12 p. 2162 - 2168

piperonal

CAS#:120-57-0

CI 1020

CAS#:162256-50-0

Literature: Journal of Medicinal Chemistry, , vol. 42, # 12 p. 2162 - 2168

3,4,5-Trimethox...

CAS#:86-81-7

N/A

CAS#:162256-49-7

CI 1020

CAS#:162256-50-0

Literature: Journal of Medicinal Chemistry, , vol. 38, # 8 p. 1259 - 1263

3-(1,3-BENZODIO...

CAS#:144309-50-2

CI 1020

CAS#:162256-50-0

Literature: Journal of Medicinal Chemistry, , vol. 42, # 12 p. 2162 - 2168

Precursor 3
CAS#:162256-48-6 2-(1,3-benzodio... CAS#:120-57-0 piperonal CAS#:86-81-7 3,4,5-Trimethox...
DownStream 0

PPADS tetrasodium salt

CI 1020

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CI 1020
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

CI 1020 suppliers

CI 1020 price

CI 1020

Use of CI 1020

Names

CI 1020 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.