CI 1020

Modify Date: 2024-01-09 18:22:42

CI 1020 structure	Common Name	CI 1020
	CAS Number	162256-50-0	Molecular Weight	506.50
	Density	1.351g/cm3	Boiling Point	722.338ºC at 760 mmHg
	Molecular Formula	C₂₈H₂₆O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	242.505ºC

Use of CI 1020

CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration[1][2][3].

Name	3-(1,3-benzodioxol-5-yl)-5-hydroxy-5-(4-methoxyphenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]furan-2-one
Synonym	More Synonyms

Description	CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETA:0.3 nM (IC50)
References	[1]. Maguire JJ, et al. ETA receptor antagonists inhibit intimal smooth muscle cell proliferation in human vessels. Clin Sci (Lond). 2002 Aug;103 Suppl 48:184S-188S. [2]. Doherty AM, et al. Discovery and development of an endothelin A receptor-selective antagonist PD 156707. Pharm Biotechnol. 1998;11:81-112. [3]. Jones RD, et al. The effect of the endothelin ET(A) receptor antagonist CI-1020 on hypoxic pulmonary vasoconstriction. Eur J Pharmacol. 1999 Jun 25;374(3):367-75. [4]. Sheedy W, et al. The effect of the ETA receptor antagonist (CI-1020) in rats with established hypoxic pulmonary hypertension. Pulm Pharmacol Ther. 1998 Apr-Jun;11(2-3):173-6.

Density	1.351g/cm3
Boiling Point	722.338ºC at 760 mmHg
Molecular Formula	C₂₈H₂₆O₉
Molecular Weight	506.50
Flash Point	242.505ºC
Exact Mass	506.15800
PSA	101.91000
LogP	3.84810
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.623