CI 1020
Names
Biological Activity
[Description]:
CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration[1][2][3].
[Related Catalog]:
[Target]
ETA:0.3 nM (IC50)
[References]
Chemical & Physical Properties
[ Density]:
1.351g/cm3
[ Boiling Point ]:
722.338ºC at 760 mmHg
[ Molecular Formula ]:
C28H26O9
[ Molecular Weight ]:
506.50
[ Flash Point ]:
242.505ºC
[ Exact Mass ]:
506.15800
[ PSA ]:
101.91000
[ LogP ]:
3.84810
[ Vapour Pressure ]:
0mmHg at 25°C
[ Index of Refraction ]:
1.623