CI 583
Modify Date: 2025-08-25 10:45:24
CI 583 structure
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Common Name | CI 583 | ||
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| CAS Number | 67254-91-5 | Molecular Weight | 336.14600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H12Cl2NNaO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CI 583Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4]. |
| Name | sodium meclofenamate monohydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively[1][2][3][4]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Meclofenamic acid sodium hydrate (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner[1]. Meclofenamic acid sodium hydrate inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins[2]. Meclofenamic acid sodium hydrate inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins[2]. Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 0, 12.5, 25, 50, 100 μM Incubation Time: 24 h Result: Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO. |
| References |
| Molecular Formula | C14H12Cl2NNaO3 |
|---|---|
| Molecular Weight | 336.14600 |
| Exact Mass | 335.00900 |
| PSA | 61.39000 |
| LogP | 3.41760 |
| Precursor 0 | |
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| DownStream 1 | |
CAS#:3254-79-3| sodium,2-(2,6-dichloro-3-methylanilino)benzoate,hydrate |
| Meclomen |
| UNII-94NJ818U2W |
| Lenidolor |
| Meclodol |
| Meclofenamic acid sodium salt monohydrate |