6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine

Modify Date: 2024-04-03 21:19:08

6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine Structure
6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine structure
Common Name 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine
CAS Number 161923-50-8 Molecular Weight 428.78
Density N/A Boiling Point N/A
Molecular Formula C16H17ClN4O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine


6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine
Synonym More Synonyms

  Biological Activity

Description 6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C16H17ClN4O8
Molecular Weight 428.78
Exact Mass 428.07300
PSA 151.96000
LogP 0.50920
Index of Refraction 1.678

 Synthetic Route

~97%

6-Chloro-2-hydroxy-9-(2',3',5'-tri-O-acetyl-b-D-ribofuranosyl)purine Structure

6-Chloro-2-hydr...

CAS#:161923-50-8

Literature: Moorman, Allan R. Patent: US2003/199686 A1, 2003 ; Location in patent: Page/Page column 6 ;

 Precursor & DownStream

Precursor  1

DownStream  1

 Synonyms

6-chloropyrazine-2-ylhydrazine
2-chloro-6-hydrazinopyridazine
2-Hydrazino-6-chlorpyrazin
2-Chloro-6-hydrazinylpyrazine
2',3',5'-triacetyl-6-chloroguanosine
6-chloro-2-hydrazinopyrazine
2-chloro-6-hydrazino-pyrazine
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