Teixobactin
Modify Date: 2025-08-25 18:33:00
Teixobactin structure
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Common Name | Teixobactin | ||
|---|---|---|---|---|
| CAS Number | 1613225-53-8 | Molecular Weight | 1242.47000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C58H95N15O15 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TeixobactinTeixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3]. |
| Name | Teixobactin |
|---|---|
| Synonym | More Synonyms |
| Description | Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Teixobactin (0-128 µg/mL) 显示出抗菌活性，对 MRSA ATCC 33591 的 MIC 值为 0.25 µg/mL[2]。 Teixobactin (0-24 h) 显示出抗菌活性，对 Clostridium difficile, Bacillus anthracis 的 MIC 值分别为5、20 ng/mL[3]。 |
| In Vivo | Teixobactin (1-20 mg/kg; i.v.; once) 在小鼠体内表现出抗菌活性[3]。 Animal Model: Female CD-1 mice (MRSA ATCC33591)[3] Dosage: 1, 2.5, 5, 10, 20 mg/kg Administration: i.v.; once; one hour post-infection Result: Showed good antibacterial activity and all treated animals survived. |
| References |
| Molecular Formula | C58H95N15O15 |
|---|---|
| Molecular Weight | 1242.47000 |
| Exact Mass | 1241.71000 |
| PSA | 460.79000 |
| LogP | 1.52230 |
| InChIKey | LMBFAGIMSUYTBN-MPZNNTNKSA-N |
| SMILES | CCC(C)C(NC(=O)C(Cc1ccccc1)NC)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(C(=O)NC(CO)C(=O)NC1C(=O)NC(C)C(=O)NC(CC2CN=C(N)N2)C(=O)NC(C(C)CC)C(=O)OC1C)C(C)CC)C(C)CC |
| (R)-N1-((2R,3S)-1-(((2S,3S)-1-(((S)-1-(((3S,6S,9S,12R,13S)-3-((S)-sec-butyl)-6-(((S)-2-iminoimidazolidin-4-yl)methyl)-9,13-dimethyl-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecan-12-yl)amino)-3-hydroxy-1-oxopropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-2-((S)-3-hydroxy-2-((2S,3S)-3-methyl-2-((R)-2-(methylamino)-3-phenylpropanamido)pentanamido)propanamido)pentanediamide |