1613225-53-8

1613225-53-8 structure

Name: Teixobactin
Chemical Name: Teixobactin
CAS Number: 1613225-53-8
Molecular Formula: C₅₈H₉₅N₁₅O₁₅
Molecular Weight: 1242.47000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-12-24 17:34:39
Modify Date: 2025-08-25 18:33:00
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].

Name	Teixobactin
Synonyms	(R)-N1-((2R,3S)-1-(((2S,3S)-1-(((S)-1-(((3S,6S,9S,12R,13S)-3-((S)-sec-butyl)-6-(((S)-2-iminoimidazolidin-4-yl)methyl)-9,13-dimethyl-2,5,8,11-tetraoxo-1-oxa-4,7,10-triazacyclotridecan-12-yl)amino)-3-hydroxy-1-oxopropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-2-((S)-3-hydroxy-2-((2S,3S)-3-methyl-2-((R)-2-(methylamino)-3-phenylpropanamido)pentanamido)propanamido)pentanediamide

Description	Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Teixobactin (0-128 µg/mL) 显示出抗菌活性，对 MRSA ATCC 33591 的 MIC 值为 0.25 µg/mL[2]。 Teixobactin (0-24 h) 显示出抗菌活性，对 Clostridium difficile, Bacillus anthracis 的 MIC 值分别为5、20 ng/mL[3]。
In Vivo	Teixobactin (1-20 mg/kg; i.v.; once) 在小鼠体内表现出抗菌活性[3]。 Animal Model: Female CD-1 mice (MRSA ATCC33591)[3] Dosage: 1, 2.5, 5, 10, 20 mg/kg Administration: i.v.; once; one hour post-infection Result: Showed good antibacterial activity and all treated animals survived.
References	[1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9.