BAY-747
Modify Date: 2025-11-05 20:59:03
BAY-747 structure
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Common Name | BAY-747 | ||
|---|---|---|---|---|
| CAS Number | 1609341-78-7 | Molecular Weight | 416.473 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H26F2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAY-747BAY-747 (BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator.Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo. |
| Name | BAY-747 |
|---|
| Description | BAY-747 (BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator.Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo. |
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| References | 1. Nelissen E, et al. Sci Rep. 2022 Mar 4;12(1):3589. |
| Molecular Formula | C22H26F2N4O2 |
|---|---|
| Molecular Weight | 416.473 |
| InChIKey | MITNUFZPBQIMAT-UHFFFAOYSA-N |
| SMILES | CCC(C)(N)CNC(=O)c1c(C)nc2c(OCc3c(F)cccc3F)cc(C)cn12 |