Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

Modify Date: 2025-08-27 10:14:35

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure
Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate structure
Common Name Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
CAS Number 15991-13-6 Molecular Weight 234.20500
Density N/A Boiling Point N/A
Molecular Formula C12H10O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate


Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection[1][2][3].

 Names

Name methyl 2-(7-hydroxy-2-oxochromen-4-yl)acetate
Synonym More Synonyms

  Biological Activity

Description Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection[1][2][3].
Related Catalog
In Vitro Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate (compound 2) exhibits the maximum absorption (λabs~322 nm) and emission (λem~387 nm) wavelengths[2].
References

[1]. Nascimento JSD, et al. Mapping the Biotransformation of Coumarins through Filamentous Fungi. Molecules. 2019 Sep 29;24(19).

[2]. Lizzul-Jurse A, et al. Readily functionalizable phosphonium-tagged fluorescent coumarins for enhanced detection of conjugates by mass spectrometry. Org Biomol Chem. 2016 Aug 10;14(32):7777-91.

[3]. Giovannini G, et al. Coumarin-based, switchable fluorescent substrates for enzymatic bacterial detection. Talanta. 2018 Oct 1;188:448-453.

 Chemical & Physical Properties

Molecular Formula C12H10O5
Molecular Weight 234.20500
Exact Mass 234.05300
PSA 76.74000
LogP 1.21410

 Safety Information

HS Code 2932209090

 Synthetic Route

~96%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Holmes, Christopher P.; Macher, Natalie; Grove, J. Russell; Jang, Larry; Irvine, Jennifer D. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3382 - 3385

~91%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Smitha; Reddy, Ch. Sanjeeva Synthetic Communications, 2004 , vol. 34, # 21 p. 3997 - 4003

~60%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Dubovik; Garazd; Khilya Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 3 p. 277 - 281

~%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Brubaker; DeRuiter; Whitmer Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1094 - 1099

~%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Baker et al. Journal of the Chemical Society, 1950 , p. 170,172

~%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Baker et al. Journal of the Chemical Society, 1950 , p. 170,172

~%

Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate Structure

Methyl 2-(7-hyd...

CAS#:15991-13-6

Literature: Holmes, Christopher P.; Macher, Natalie; Grove, J. Russell; Jang, Larry; Irvine, Jennifer D. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3382 - 3385

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
methyl (7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester
7-hydroxy-4-methoxycarbonylmethyl-2H-chromen-2-one
methyl 2-(7-hydroxy-2-oxochromen-4-yl) acetate
(7'-hydroxycoumarin-4-yl)acetic acid methyl ester
7-hydroxycoumarin-4-acetic acid methyl ester
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