Mc-Val-Cit-PABC-PNP
Modify Date: 2025-08-25 19:08:01
Mc-Val-Cit-PABC-PNP structure
|
Common Name | Mc-Val-Cit-PABC-PNP | ||
|---|---|---|---|---|
| CAS Number | 159857-81-5 | Molecular Weight | 737.756 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1034.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C35H43N7O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 579.4±34.3 °C | |
Use of Mc-Val-Cit-PABC-PNPMc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
| Name | MC-Val-Cit-PABC-PNP |
|---|---|
| Synonym | More Synonyms |
| Description | Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
|---|---|
| Related Catalog | |
| References |
[1]. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1034.5±65.0 °C at 760 mmHg |
| Molecular Formula | C35H43N7O11 |
| Molecular Weight | 737.756 |
| Flash Point | 579.4±34.3 °C |
| Exact Mass | 737.302063 |
| PSA | 261.15000 |
| LogP | 2.71 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.599 |
| Storage condition | 2~8℃ |
|
~%
Mc-Val-Cit-PABC-PNP CAS#:159857-81-5 |
| Literature: WO2007/8603 A1, ; Page/Page column 137; 166; 167 ; |
| maleimidocaproyl-val-Cit-PAB-OCOpNP |
| N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide |
| L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]- |
| 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl (4-nitrophenyl)carbonate |
| N-[6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide |
| N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide |
| maleimido-caproyl-valine-citrulline-para-aminobenzyl-4-nitrophenylcarbonate |
| MC-VAL-CIT-PAB-PNB |
| Mc-Val-Cit-PABC-PNP |