Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

Modify Date: 2024-01-02 20:13:44

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde structure	Common Name	Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde
	CAS Number	158442-41-2	Molecular Weight	618.761
	Density	1.1±0.1 g/cm3	Boiling Point	844.2±65.0 °C at 760 mmHg
	Molecular Formula	C₃₂H₅₀N₄O₈	Melting Point	N/A
	MSDS	USA	Flash Point	464.4±34.3 °C

Use of Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas[1].

Name	N-[(Phenylmethoxy)carbonyl]-L-isoleucyl-L-α-glutamyl-tert-butylester-N-[(1S)-1-formyl-3-methylbutyl]-L-alaninamide
Synonym	More Synonyms

Description	PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome
In Vitro	PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1]. PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control[1]. PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%[1]. PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1]. Cell Cytotoxicity Assay[1] Cell Line: BC3, BCBL1, Ramos, BJAB cells Concentration: Incubation Time: 24 h Result: Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively). Western Blot Analysis[1] Cell Line: HBL6 cells Concentration: 50 nM Incubation Time: 6 h Result: Decreased the NF-κB activity by 52%.
References	[1]. Saji C, et al. Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells. Biochem Biophys Res Commun. 2011; 415(4):573-8.

Density	1.1±0.1 g/cm3
Boiling Point	844.2±65.0 °C at 760 mmHg
Molecular Formula	C₃₂H₅₀N₄O₈
Molecular Weight	618.761
Flash Point	464.4±34.3 °C
Exact Mass	618.362854
PSA	169.00000
LogP	5.79
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.510
Storage condition	−20°C

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Figueiredo-Pereira, M.E., et al.

J. Neurochem. 63 , 5433, (1994)

tert-Butyl (4S)-4-{[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanoyl]amino}-5-{[(2S)-1-{[(2S)-4-methyl-1-oxopentan-2-yl]amino}-1-oxopropan-2-yl]amino}-5-oxopentanoate (non-preferred name)

PROTEASOME INHIBITOR I

M.W. 618.77 C32H50N4O8

N-Cb

2-Methyl-2-propanyl (4S)-4-{[(2S,3S)-2-{[(benzyloxy)carbonyl]amino}-3-methylpentanoyl]amino}-5-{[(2S)-1-{[(2S)-4-methyl-1-oxo-2-pentanyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate (non-preferred name)

DC Chemicals Limited
China
Product Name: PSI
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Proteasome Inhibitor I
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

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Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

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