Terodiline

Modify Date: 2024-01-02 14:33:25

Terodiline structure	Common Name	Terodiline
	CAS Number	15793-40-5	Molecular Weight	281.44
	Density	0.956g/cm3	Boiling Point	390.9ºC at 760mmHg
	Molecular Formula	C₂₀H₂₇N	Melting Point	N/A
	MSDS	N/A	Flash Point	168.9ºC

Use of Terodiline

Terodiline is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline also is a Ca2+ blocker. Terodiline acts as a treatment for urinary frequency and urge incontinence[1].

Name	1-methyl-3,3-diphenylpropylamine
Synonym	More Synonyms

Description	Terodiline is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline also is a Ca2+ blocker. Terodiline acts as a treatment for urinary frequency and urge incontinence[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	mAChR[1] Ca2+ channel[1]
In Vivo	Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1]. Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1] Dosage: 80 mg/kg Administration: Administered S.C. Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
References	[1]. Noronha-Blob L, et al. (+/-)-Terodiline: an M1-selective muscarinic receptor antagonist. In vivo effects at muscarinic receptors mediating urinary bladder contraction, mydriasis and salivary secretion. Eur J Pharmacol. 1991 Aug 29;201(2-3):135-42.

Density	0.956g/cm3
Boiling Point	390.9ºC at 760mmHg
Molecular Formula	C₂₀H₂₇N
Molecular Weight	281.44
Flash Point	168.9ºC
Exact Mass	225.15200
PSA	26.02000
LogP	4.25610
Vapour Pressure	2.57E-06mmHg at 25°C
Index of Refraction	1.534

HS Code	2921499090

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

RS-terodiline

Terodilina

Bicor

Terodiline

2-tert-Butylamino-4,4-diphenylbutan

Terodilinum

RARECHEM AN KC 0196

Terodiline

Use of Terodiline

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Terodiline Biological Activity

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