4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline
Modify Date: 2025-08-25 00:31:59
![4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline Structure](https://image.chemsrc.com/caspic/199/1573029-17-0.png)
4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline structure
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Common Name | 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline | ||
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| CAS Number | 1573029-17-0 | Molecular Weight | 282.312 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 470.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H15FN2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 238.2±28.7 °C | |
Use of 4-[6-(2-Fluoroethoxy)-2-quinolinyl]anilineTHK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1]. |
| Name | 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline |
|---|---|
| Synonym | More Synonyms |
| Description | THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1]. |
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| Related Catalog | |
| In Vivo | THK-523 crosses the blood–brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. Animal Model: Brain of tau transgenic mice[1] Dosage: 0.35 μg/kg Administration: Intravenous injection;25-30 mins Result: Overexpressed Tau in brain. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.3±45.0 °C at 760 mmHg |
| Molecular Formula | C17H15FN2O |
| Molecular Weight | 282.312 |
| Flash Point | 238.2±28.7 °C |
| Exact Mass | 282.116852 |
| LogP | 3.01 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.635 |
| InChIKey | ZGJOXECWZKCGBV-UHFFFAOYSA-N |
| SMILES | Nc1ccc(-c2ccc3cc(OCCF)ccc3n2)cc1 |
| 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline |
| Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]- |
| THK-523 |