1573029-17-0

1573029-17-0 structure

Name: 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline
Chemical Name: 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline
CAS Number: 1573029-17-0
Molecular Formula: C₁₇H₁₅FN₂O
Molecular Weight: 282.312
Catalog: Research Areas Neurological Disease
Create Date: 2018-12-09 17:13:09
Modify Date: 2025-08-25 00:31:59
THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].

Name	4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline
Synonyms	4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]- THK-523

Description	THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease
In Vivo	THK-523 crosses the blood–brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. Animal Model: Brain of tau transgenic mice[1] Dosage: 0.35 μg/kg Administration: Intravenous injection;25-30 mins Result: Overexpressed Tau in brain.
References	[1]. Ryuichi Harada, et al. Comparison of the binding characteristics of [¹⁸F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):125-32. [2]. Michelle T Fodero-Tavoletti, 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain. 2011 Apr;134(Pt 4):1089-100.