(R)-BAY1238097

Modify Date: 2025-09-20 19:42:08

(R)-BAY1238097 Structure
(R)-BAY1238097 structure
 Common Name (R)-BAY1238097
CAS Number 1564269-85-7 Molecular Weight 451.56
Density N/A Boiling Point N/A
Molecular Formula C25H33N5O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (R)-BAY1238097


(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome[1][2].

 Names

Name (R)-BAY1238097

 (R)-BAY1238097 Biological Activity

Description (R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome[1][2].
Related Catalog
Target

BET[1].

References

[1]. Lejeune, P., et al. (2015) Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models. Cancer Research, 75(15 Suppl), 884.

[2]. Bernasconi E, et al. Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma. Br J Haematol. 2017 Sep;178(6):936-948.

 Chemical & Physical Properties

Molecular Formula C25H33N5O3
Molecular Weight 451.56
InChIKey CJIPEACKIJJYED-QGZVFWFLSA-N
SMILES CNC(=O)N1N=C(c2ccc(N3CCN(C)CC3)cc2)c2cc(OC)c(OC)cc2CC1C
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