1564269-85-7

1564269-85-7 structure

Name: (R)-BAY1238097
Chemical Name: (R)-BAY1238097
CAS Number: 1564269-85-7
Molecular Formula: C₂₅H₃₃N₅O₃
Molecular Weight: 451.56
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-06-01 12:15:33
Modify Date: 2024-01-19 17:25:12
(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome[1][2].

Name	(R)-BAY1238097

Description	(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BET[1].
References	[1]. Lejeune, P., et al. (2015) Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models. Cancer Research, 75(15 Suppl), 884. [2]. Bernasconi E, et al. Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma. Br J Haematol. 2017 Sep;178(6):936-948.

Molecular Formula	C₂₅H₃₃N₅O₃
Molecular Weight	451.56