dictyostatin
Modify Date: 2024-01-14 08:34:28
dictyostatin structure
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Common Name | dictyostatin | ||
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| CAS Number | 156312-07-1 | Molecular Weight | 532.75200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H52O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of dictyostatinDictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies[1][2][3]. |
| Name | dictyostatin |
|---|---|
| Synonym | More Synonyms |
| Description | Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies[1][2][3]. |
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| Related Catalog | |
| In Vitro | Dictyostatin (0-100 nM; 72-120 h) 在癌细胞中显示出抗增殖活性[2]。 Cell Viability Assay[2] Cell Line: A549, EpoB40/A549, 1A9, 1A9/PTX10, 1A9/PTX22 cells Concentration: 0-100 nM Incubation Time: 72-120 h Result: Showed antiproliferative activity with GI50s of 0.5, 5.1, 1.3, 18.8, 5.1 nM for A549, EpoB40/A549, 1A9, 1A9/PTX10, 1A9/PTX22 cells, respectively. |
| In Vivo | Dictyostatin (0.3、1 mg/kg；腹腔注射；每周一次，持续 3 个月) 可改善小鼠的 MT 密度并减少轴突营养不良[3]。 Animal Model: 6-month old male B6 PS19 tau Tg mice[3] Dosage: 0.3, 1 mg/kg Administration: I.p.; once-weekly for 3 months Result: Improved MT density and reduced axonal dystrophy, with a reduction of tau pathology and a trend toward increased hippocampal neuron survival relative to vehicle-treated PS19 mice, caused a significant reduction of insoluble TauAcK280. |
| References |
| Molecular Formula | C32H52O6 |
|---|---|
| Molecular Weight | 532.75200 |
| Exact Mass | 532.37600 |
| PSA | 107.22000 |
| LogP | 5.14320 |
| (-)dictyostatin |
| dicytostatin |
| (3Z,5E,11Z)-(7R,8S,10S,13S,14R,15S,17S,20R,21S,22S)-8,10,14,20-Tetrahydroxy-7,13,15,17,21-pentamethyl-22-((Z)-(S)-1-methyl-penta-2,4-dienyl)-oxacyclodocosa-3,5,11-trien-2-one |
| (-)-dictyostatin |
| dictyostatin 1 |
| (7R,8S,10S,13S,14R,15S,17S,20R,21S,22S)-8,10,14,20-tetrahydroxy-7,13,15,17,21-pentamethyl-22-((1S)-1-methylpenta-2,4-dienyl)oxacyclodocosa-3,5,11-trien-2-one |