Compound C108
Modify Date: 2025-08-27 18:03:31
Compound C108 structure
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Common Name | Compound C108 | ||
|---|---|---|---|---|
| CAS Number | 15533-09-2 | Molecular Weight | 270.283 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H14N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Compound C108Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2]. |
| Name | Compound C108 |
|---|---|
| Synonym | More Synonyms |
| Description | Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2]. |
|---|---|
| Related Catalog | |
| Target |
G3BP2[1] |
| In Vitro | Compound C108 (1 μM; 24 h) 对 BT474 细胞具有抗肿瘤活性[1]。 Compound C108 (4 μM; 24 h) 显著降低过表达 G3BP2 的 KYSE410 细胞和转染 LINC01554的 KYSE30 细胞中 G3BP2 蛋白的表达[2]。 Compound C108 (4 μM; 24 h) 减弱 KYSE410、KYSE30 和 KYSE150 细胞的 ESCC 细胞转移、迁移和侵袭[2]。 Western Blot Analysis[2] Cell Line: G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells Concentration: 4 μM Incubation Time: 24 h Result: Decreased the protein level of G3BP2 and HDGF. |
| In Vivo | Compound C108 (1 μM; 24 h) 靶向并减少肿瘤起始细胞 (TICs)，当把 Compound C108 处理过的 BT-474 细胞注射到雌性非肥胖糖尿病/严重联合免疫缺陷 (NOD-SCID) 小鼠的乳腺脂肪垫中，进行有限稀释异种移植试验时，Compound C108 导致肿瘤起始细胞 (TICs) 数目降低[1]。 |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C15H14N2O3 |
| Molecular Weight | 270.283 |
| Exact Mass | 270.100433 |
| LogP | 3.52 |
| Index of Refraction | 1.607 |
| 2-Hydroxy-N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]benzohydrazide |
| Benzoic acid, 2-hydroxy-, 2-[(1E)-1-(2-hydroxyphenyl)ethylidene]hydrazide |
| Compound C108 |