2223169-38-6
2223169-38-6 structure
- Name: Compound 621433144
- Chemical Name: Compound 621433144
- CAS Number: 2223169-38-6
- Molecular Formula: C18H27N3O
- Molecular Weight: 301.434
- Create Date: 2020-01-20 13:06:55
- Modify Date: 2025-09-12 17:03:40
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Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity; Compound 621433144 was also functionally selective, with a 17-fold bias towards Gi signalling versus β-arrestin recruitment, compared to the characteristic agonist quinpirole.
| Name | Compound 621433144 |
|---|
| Description | Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity; Compound 621433144 was also functionally selective, with a 17-fold bias towards Gi signalling versus β-arrestin recruitment, compared to the characteristic agonist quinpirole. |
|---|---|
| References | References 1. Lyu J, et al. Nature. 2019 Feb 6. doi: 10.1038/s41586-019-0917-9. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C18H27N3O |
|---|---|
| Molecular Weight | 301.434 |