Ritonavir

Modify Date: 2024-01-02 09:43:43

Ritonavir structure	Common Name	Ritonavir
	CAS Number	155213-67-5	Molecular Weight	720.944
	Density	1.2±0.1 g/cm3	Boiling Point	947.0±65.0 °C at 760 mmHg
	Molecular Formula	C₃₇H₄₈N₆O₅S₂	Melting Point	120-122°C
	MSDS	Chinese USA	Flash Point	526.6±34.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Ritonavir

Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.

Name	ritonavir
Synonym	More Synonyms

Description	Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
In Vitro	Ritonavir is an inhibitor of CYP3A4 mediated testosterone 6β-hydroxylation with mean Ki of 19 nM and also inhibits tolbutamide hydroxylation with IC50 of 4.2 μM[1]. Ritonavir is found to be a potent inhibitor of CYP3A-mediated biotransformations (nifedipine oxidation with IC50 of 0.07 mM, 17alpha-ethynylestradiol 2-hydroxylation with IC50 of 2 mM; terfenadine hydroxylation with IC50 of 0.14 mM). Ritonavir is also an inhibitor of the reactions mediated by CYP2D6 (IC50=2.5 mM) and CYP2C9/10 (IC50=8.0 mM)[2]. Ritonavir results in an increase in cell viability in uninfected human PBMC cultures. Ritonavir markedly decreases the susceptibility of PBMCs to apoptosis correlated with lower levels of caspase-1 expression, decreases in annexin V staining, and reduces caspase-3 activity in uninfected human PBMC cultures. Ritonavir inhibits induction of tumor necrosis factor (TNF) production by PBMCs and monocytes in a time- and dose-dependent manner at nontoxic concentrations[3]. Ritonavir inhibits p-glycoprotein-mediated extrusion of saquinavir with an IC50 of 0.2 μM, indicating a high affinity of ritonavir for p-glycoprotein[4]. Ritonavir inhibits human liver microsomal metabolism of ABT-378 potently with Ki of 13 nM. Ritonavir combined with ABT-378 (at 3:1 and 29:1 ratios) inhibits CYP3A (IC50=1.1 and 4.6 μM), albeit less potently than Ritonavir (IC50=0.14 μM)[5].
References	[1]. Eagling VA, et al. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors, ritonavir, saquinavir and indinavir. Br J Clin Pharmacol. 1997 Aug;44(2):190-4. [2]. Kumar GN, et al. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J Pharmacol Exp Ther. 1996 Apr;277(1):423-31. [3]. Weichold FF, et al. HIV-1 protease inhibitor ritonavir modulates susceptibility to apoptosis of uninfected T cells. J Hum Virol. 1999 Sep-Oct;2(5):261-9. [4]. Drewe J, et al. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochem Pharmacol. 1999 May 15;57(10):1147-52. [5]. Kumar GN, et al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug;27(8):902-8.

Density	1.2±0.1 g/cm3
Boiling Point	947.0±65.0 °C at 760 mmHg
Melting Point	120-122°C
Molecular Formula	C₃₇H₄₈N₆O₅S₂
Molecular Weight	720.944
Flash Point	526.6±34.3 °C
Exact Mass	720.312744
PSA	202.26000
LogP	5.28
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.600
Storage condition	-20°C Freezer

Ritonavir MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P261-P280-P301 + P312 + P330
Hazard Codes	Xi
Risk Phrases	R36/38:Irritating to eyes and skin .
Safety Phrases	26-37/39
RIDADR	NONH for all modes of transport
RTECS	XA5310000
HS Code	2942000000

2,5-DIOXOPYRROL...

CAS#:224631-15-6

(2S,3S,5S)-5-Am...

CAS#:144164-11-4

Ritonavir

CAS#:155213-67-5

Literature: WO2006/90264 A1, ; Page/Page column 23-24 ;

H-Val-OmeHCl

CAS#:6306-52-1

Ritonavir

CAS#:155213-67-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

4-Nitrophenyl 1...

CAS#:144163-97-3

Ritonavir

CAS#:155213-67-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

2-Isopropyl-4-(...

CAS#:154212-60-9

Ritonavir

CAS#:155213-67-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

N-(4-Nitropheno...

CAS#:162537-10-2

Ritonavir

CAS#:155213-67-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

N-((N-Methyl-N-...

CAS#:154248-99-4

Ritonavir

CAS#:155213-67-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

N-[2-Isopropylt...

CAS#:154212-61-0

(2S,3S,5S)-5-Am...

CAS#:144164-11-4

Ritonavir

CAS#:155213-67-5

Literature: Journal of Medicinal Chemistry, , vol. 41, # 4 p. 602 - 617

Precursor 8
CAS#:224631-15-6 2,5-DIOXOPYRROL... CAS#:144164-11-4 (2S,3S,5S)-5-Am... CAS#:6306-52-1 H-Val-OmeHCl CAS#:144163-97-3 4-Nitrophenyl 1...
CAS#:154212-60-9 2-Isopropyl-4-(... CAS#:162537-10-2 N-(4-Nitropheno... CAS#:154248-99-4 N-((N-Methyl-N-... CAS#:154212-61-0 N-[2-Isopropylt...
DownStream 0

HS Code	2942000000

In vitro and in vivo release characteristics of Tacrolimus (FK506) from an episcleral drug-delivery implant.

J. Ocul. Pharmacol. Ther. 30(8) , 670-80, (2014)

To investigate the in vitro and in vivo release characteristics of Tacrolimus (FK506) from an episcleral drug-delivery implant.For in vitro experiments, Tacrolimus-loaded implants (0.5 mL; at concentr...

Cell-free microfluidic determination of P-glycoprotein interactions with substrates and inhibitors.

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The membrane protein P-glycoprotein (P-gp) plays key roles in the oral bioavailability of drugs, their blood brain barrier passage as well as in multidrug resistance. For new drug candidates it is man...

Molecular cloning and functional characterization of a rainbow trout liver Oatp.

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Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics...

[5S-(5R*,8R*,10R*,11R*)]-10-Hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid 5-thiazolylmethyl ester

Norvir

Ritonavir

EINECS 208-127-9

N-[(2S,4S,5S)-4-Hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N-{[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}-L-valinamide

Ritonavi

Carbamic acid, N-[(1S,2S,4S)-2-hydroxy-4-[[(2S)-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]-1-oxobutyl]amino]-5-phenyl-1-(phenylmethyl)pentyl]-, 5-thiazolylmethyl ester

ABT-538

(1E,2S)-N-[(2S,4S,5S)-4-Hydroxy-5-{(E)-[hydroxy(1,3-thiazol-5-ylmethoxy)methylene]amino}-1,6-diphenyl-2-hexanyl]-2-[(E)-(hydroxy{[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)amino}methylene)amino]-3-methylbutanimidic acid

1,3-Thiazol-5-ylmethyl-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-({(2S)-3-methyl-2-[(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)amino]butanoyl}amino)-5-phenylpentyl]carbamat

N-[(1S,3S,4S)-1-benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl]-N-(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide

[(1S,2S,4S)-1-benzyl-2-hydroxy-4-({(2S)-3-méthyl-2-[(méthyl{[2-(1-méthyléthyl)-1,3-thiazol-4-yl]méthyl}carbamoyl)amino]butanoyl}amino)-5-phénylpentyl]carbamate de 1,3-thiazol-5-ylméthyle

Butanimidic acid, N-[(1S,3S,4S)-3-hydroxy-4-[[(1E)-hydroxy(5-thiazolylmethoxy)methylene]amino]-5-phenyl-1-(phenylmethyl)pentyl]-2-[[(1E)-hydroxy[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]methylene]amino]-3-methyl-, (1E,2S)-

N-[(2S,4S,5S)-4-Hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}-2-hexanyl]-N-{[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}-L-valinamide

carbamic acid, [(1S,2S,4S)-2-hydroxy-4-[[(2S)-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]-1-oxobutyl]amino]-5-phenyl-1-(phenylmethyl)pentyl]-, 5-thiazolylmethyl es

N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N2-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide

Liponavir Core

1,3-thiazol-5-ylmethyl [(1S,2S,4S)-1-benzyl-2-hydroxy-4-({(2S)-3-methyl-2-[(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)amino]butanoyl}amino)-5-phenylpentyl]carbamate

A-84538 ABT-538 Abbott 84538

Norvi

(2S,3S,5S)-5-[N-[N-[[N-methyl-N-[(2-isopropyl-4-thiazolyl)methyl]amino]carbonyl]valinyl]amino]-2-[N-[(5-thiazolyl)methoxycarbonyl]amino]-1,6-diphenyl-3-hydroxyhexane

RITONA

MFCD04115732

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Ritonavir
Price: ￥648.0/10mg ￥2658.0/50mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Ritonavir
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Ritonavir
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Ritonavir
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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Ritonavir

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