GSK-199 hydrochloride
Modify Date: 2024-02-17 11:28:37
GSK-199 hydrochloride structure
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Common Name | GSK-199 hydrochloride | ||
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| CAS Number | 1549811-53-1 | Molecular Weight | 468.979 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H29ClN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GSK-199 hydrochlorideGSK-199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay; shows high specificity for PAD4 over PAD1/2/3/6; affects cellular citrullination and mimic the deficiency in NET production in mice; significantly decreases in complement C3 deposition in both synovium and cartilage in mice. |
| Name | (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride |
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| Synonym | More Synonyms |
| Description | GSK-199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay; shows high specificity for PAD4 over PAD1/2/3/6; affects cellular citrullination and mimic the deficiency in NET production in mice; significantly decreases in complement C3 deposition in both synovium and cartilage in mice. |
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| References | References 1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91. 2. Willis VC, et al. Clin Exp Immunol. 2017 May;188(2):263-274. 3. Slade DJ, et al. ACS Chem Biol. 2015 Apr 17;10(4):1043-53. View Related Products by Target Protein Arginine Deiminase (PAD) |
| Molecular Formula | C24H29ClN6O2 |
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| Molecular Weight | 468.979 |
| Exact Mass | 468.204041 |
| (R)-(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride |
| [(3R)-3-Amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]methanone hydrochloride (1:1) |
| Methanone, [(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-, hydrochloride (1:1) |