Atreleuton

Modify Date: 2024-01-02 12:26:04

Atreleuton structure	Common Name	Atreleuton
	CAS Number	154355-76-7	Molecular Weight	318.36600
	Density	1.37g/cm3	Boiling Point	506.7ºC at 760mmHg
	Molecular Formula	C₁₆H₁₅FN₂O₂S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	260.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Atreleuton

Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3].

Name	1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea
Synonym	More Synonyms

Description	Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	5-LO[1]
References	[1]. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease. VIA Pharmaceuticals, Inc. [2]. Reid JJ, et al. ABT-761 (Abbott). Curr Opin Investig Drugs. 2001 Jan;2(1):68-71. [3]. Bell RL, et al. ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73.

Density	1.37g/cm3
Boiling Point	506.7ºC at 760mmHg
Molecular Formula	C₁₆H₁₅FN₂O₂S
Molecular Weight	318.36600
Flash Point	260.2ºC
Exact Mass	318.08400
PSA	95.79000
LogP	3.50170
Vapour Pressure	4.34E-11mmHg at 25°C
Index of Refraction	1.652

Atreleuton MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

5-((4-fluorophe...

CAS#:154355-88-1

(R)-(+)-N-hydro...

CAS#:154355-92-7

~17%

Atreleuton

CAS#:154355-76-7

Literature: Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

4-Fluorobenzyl ...

CAS#:459-46-1

Atreleuton

CAS#:154355-76-7

Literature: Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

2-(4-FLUOROBENZ...

CAS#:63877-96-3

Atreleuton

CAS#:154355-76-7

Literature: Brooks; Stewart; Basha; Bhatia; Ratajczyk; Martin; Craig; Kolasa; Bouska; Lanni; Harris; Malo; Carter; Bell Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4768 - 4775

[14C]-Atreleuton

(R)-N-(3-(5-(4-fluorophenylmethyl)-2-thienyl)-1-methyl-2-propynyl)-N-hydroxyurea

Atreleuton [USAN]

Atreleuton

ABT-761

Atreleuton (USAN/INN)

UNII-U301T88E1M

(R)-N-{3-[5-(4-fluorophenylmethyl)-thien-2-yl]-1-methyl-2-propynyl}-N-hydroxyurea

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[(2R)-4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxy-urea
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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