Atreleuton

Names

[ Name ]:
Atreleuton

[Synonym ]:
[14C]-Atreleuton
(R)-N-(3-(5-(4-fluorophenylmethyl)-2-thienyl)-1-methyl-2-propynyl)-N-hydroxyurea
Atreleuton [USAN]
Atreleuton
ABT-761
Atreleuton (USAN/INN)
UNII-U301T88E1M
(R)-N-{3-[5-(4-fluorophenylmethyl)-thien-2-yl]-1-methyl-2-propynyl}-N-hydroxyurea

Biological Activity

[Description]:

Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

5-LO[1]

[References]

[1]. VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease. VIA Pharmaceuticals, Inc.

[2]. Reid JJ, et al. ABT-761 (Abbott). Curr Opin Investig Drugs. 2001 Jan;2(1):68-71.

[3]. Bell RL, et al. ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents. J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73.

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
506.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₅FN₂O₂S

[ Molecular Weight ]:
318.36600

[ Flash Point ]:
260.2ºC

[ Exact Mass ]:
318.08400

[ PSA ]:
95.79000

[ LogP ]:
3.50170

[ Vapour Pressure ]:
4.34E-11mmHg at 25°C

[ Index of Refraction ]:
1.652

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Related Compounds

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