Licostinel

Modify Date: 2024-01-18 06:02:28

Licostinel Structure
Licostinel structure
Common Name Licostinel
CAS Number 153504-81-5 Molecular Weight 276.03
Density 1.757g/cm3 Boiling Point N/A
Molecular Formula C8H3Cl2N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Licostinel


Licostinel (ACEA-1021) is a glycine receptor antagonist (IC50: 59 nM). Licostinel has neuroprotective activity[1][2][3].

 Names

Name 6,7-dichloro-5-nitro-1,4-dihydroquinoxaline-2,3-dione
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.757g/cm3
Molecular Formula C8H3Cl2N3O4
Molecular Weight 276.03
Exact Mass 274.95000
PSA 111.54000
LogP 1.95460
Index of Refraction 1.647

 Synthetic Route

~93%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379

~88%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Kher, Sunil M.; Cai, Sui Xiong; Weber, Eckard; Keana, John F. W. Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5838 - 5842

~%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Kher, Sunil M.; Cai, Sui Xiong; Weber, Eckard; Keana, John F. W. Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5838 - 5842

~%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Keana; Kher; Sui Xiong Cai; Dinsmore; Glenn; Guastella; Huang; Ilyin; Lu; Mouser; Woodward; Weber Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4367 - 4379

~%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353

~%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353

~%

Licostinel Structure

Licostinel

CAS#:153504-81-5

Literature: Thorell, Jan-Olov; Stone-Elander, Sharon; Duelfer, Tim; Cai, Sui Xiong; Jones, Lawrence; Pfefferkorn, Heidi; Ciszewska, Grazyna Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 345 - 353

 Synonyms

6,7-Dichloro-5-nitro-2,3-quinoxalinedione
Licostinel
5-Nitro-6,7-dichloro-2,3-quinoxalinedione
2,3-Quinoxalinedione,6,7-dichloro-1,4-dihydro-5-nitro
5-nitro-6,7-dichloro-1,4-dihydroquinoxaline-2,3-dione
ACEA-1021
6,7-dichloro-1,4-dihydro-8-nitro-2,3-quinoxalinedione
1,4-dihydro-6,7-dichloro-5-nitroquinoxalin-2,3-dione
6,7-Dichloro-1,4-dihydro-5-nitro-2,3-quinoxalinedione
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