GNE-955
Modify Date: 2025-11-27 21:04:43
GNE-955 structure
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Common Name | GNE-955 | ||
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| CAS Number | 1527523-39-2 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-955GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively. |
| Name | GNE-955 |
|---|
| Description | GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively. |
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| Related Catalog | |
| Target |
PIM1:18 nM (Ki) PIM2:110 nM (Ki) PIM3:8 nM (Ki) |
| In Vitro | MM.1S myeloma cell line treated with a dose range of GNE-955 reveals a constellation of PIM downstream signaling events consistent with inhibition of Pim kinases[1]. |
| In Vivo | GNE-955 has excellent bioavailability in rat. Rat clearance of GNE-955 is moderate at 34 mL /min/kg with good oral exposure[1]. |
| References |
| InChIKey | FPBWUTAWSOLPQI-INIZCTEOSA-N |
|---|---|
| SMILES | COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCCC(N)C1 |