1527523-39-2
1527523-39-2 structure
- Name: GNE-955
- Chemical Name: GNE-955
- CAS Number: 1527523-39-2
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways JAK/STAT Signaling Pim
- Create Date: 2018-07-11 02:38:46
- Modify Date: 2024-04-02 21:35:40
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GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively.
| Name | GNE-955 |
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| Description | GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively. |
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| Related Catalog | |
| Target |
PIM1:18 nM (Ki) PIM2:110 nM (Ki) PIM3:8 nM (Ki) |
| In Vitro | MM.1S myeloma cell line treated with a dose range of GNE-955 reveals a constellation of PIM downstream signaling events consistent with inhibition of Pim kinases[1]. |
| In Vivo | GNE-955 has excellent bioavailability in rat. Rat clearance of GNE-955 is moderate at 34 mL /min/kg with good oral exposure[1]. |
| References |
| No Any Chemical & Physical Properties |