FL118

Modify Date: 2024-01-02 10:14:14

FL118 Structure
FL118 structure
Common Name FL118
CAS Number 151636-76-9 Molecular Weight 392.36200
Density N/A Boiling Point N/A
Molecular Formula C21H16N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FL118


(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 (HY-12486). (R)-FL118 shows anticancer activity[1].

 Names

Name 10,11-(methylenedioxy)-(20R)-camptothecin
Synonym More Synonyms

 FL118 Biological Activity

Description (R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 (HY-12486). (R)-FL118 shows anticancer activity[1].
Related Catalog
In Vitro (R)-FL118 inhibits the growth of melanoma, breast, and prostate cancer cell lines, with IC50 values of 392.7, 32.53, 129.3, 138.7, and 92.51 ng/mL in B16, MCF-7, HS578T, DU145, and MPC3 cells, respectively[1].
References

[1]. Del Poeta M, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8.

 Chemical & Physical Properties

Molecular Formula C21H16N2O6
Molecular Weight 392.36200
Exact Mass 392.10100
PSA 99.88000
LogP 1.80830

 Synonyms

FL118
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