FL118

Names

[ Name ]:
FL118

[Synonym ]:
FL118

Biological Activity

[Description]:

(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 (HY-12486). (R)-FL118 shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

(R)-FL118 inhibits the growth of melanoma, breast, and prostate cancer cell lines, with IC50 values of 392.7, 32.53, 129.3, 138.7, and 92.51 ng/mL in B16, MCF-7, HS578T, DU145, and MPC3 cells, respectively[1].

[References]

[1]. Del Poeta M, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₆N₂O₆

[ Molecular Weight ]:
392.36200

[ Exact Mass ]:
392.10100

[ PSA ]:
99.88000

[ LogP ]:
1.80830

Related Compounds

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