151636-76-9

151636-76-9 structure

Name: FL118
Chemical Name: 10,11-(methylenedioxy)-(20R)-camptothecin
CAS Number: 151636-76-9
Molecular Formula: C₂₁H₁₆N₂O₆
Molecular Weight: 392.36200
Catalog: Research Areas Cancer
Create Date: 2017-10-06 23:26:22
Modify Date: 2025-11-29 16:54:18
(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 (HY-12486). (R)-FL118 shows anticancer activity[1].

Name	10,11-(methylenedioxy)-(20R)-camptothecin
Synonyms	FL118

Description	(R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 (HY-12486). (R)-FL118 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	(R)-FL118 inhibits the growth of melanoma, breast, and prostate cancer cell lines, with IC50 values of 392.7, 32.53, 129.3, 138.7, and 92.51 ng/mL in B16, MCF-7, HS578T, DU145, and MPC3 cells, respectively[1].
References	[1]. Del Poeta M, et al. Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells. Antimicrob Agents Chemother. 1999 Dec;43(12):2862-8.