4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid

Modify Date: 2025-08-21 10:05:45

4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid structure	Common Name	4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid
	CAS Number	1510-21-0	Molecular Weight	486.73
	Density	1.1±0.1 g/cm3	Boiling Point	586.0±43.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₅₀O₄	Melting Point	178 °C
	MSDS	Chinese USA	Flash Point	179.6±21.7 °C

Use of 4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid

Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].

Name	Cholesteryl hemisuccinate
Synonym	More Synonyms

Description	Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vivo	Cholesteryl hemisuccinate（100 mg/kg；ip；AAP 前单次给药）消除 AAP（350-500 mg/kg；ip；单次给药）在 ICR 小鼠 (CD-1) 中诱导的细胞凋亡和坏死的组织学和生化诊断[1]。
References	[1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83. [2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093.

Density	1.1±0.1 g/cm3
Boiling Point	586.0±43.0 °C at 760 mmHg
Melting Point	178 °C
Molecular Formula	C₃₁H₅₀O₄
Molecular Weight	486.73
Flash Point	179.6±21.7 °C
Exact Mass	486.370911
PSA	63.60000
LogP	10.32
Vapour Pressure	0.0±3.5 mmHg at 25°C
Index of Refraction	1.529

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Precursor 3
CAS#:108-30-5 Succinic anhydride CAS#:57-88-5 cholesterol CAS#:543-20-4 SUCCINYL CHLORIDE
DownStream 1
CAS#:2387-23-7 1,3-Dicyclohexylurea

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4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid

3-cholesteryloxycarbonylpropanoic acid

Cholesteryl hydrogen succinate

EINECS 216-148-6

3-(3-cholesteryloxycarbonyl)propanoic acid

MONO-CHOLESTERYL-SUCCINATE

CHOLESTEROL HYDROGEN SUCCINATE

3β-Hydroxy-5-cholestene 3-hemisuccinate

MFCD00037705

cholesteryl hemisuccinate free acid

cholesterylsuccinate

5-Cholesten-3β-ol 3-hemisuccinate