S1R agonist 2
Modify Date: 2024-01-20 17:31:30
S1R agonist 2 structure
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Common Name | S1R agonist 2 | ||
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| CAS Number | 150085-21-5 | Molecular Weight | 309.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27NO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S1R agonist 2S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. |
| Name | S1R agonist 2 |
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| Description | S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1]. |
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| Related Catalog | |
| Target |
Sigma 1 Receptor:1.1 nM (Ki) Sigma 2 Receptor:88 nM (Ki) |
| In Vitro | S1R agonist 2 (Compound 8b; 0.1-5 μM) 均能显著增加神经生长因子 (NGF) 诱导的神经突生长，且呈剂量依赖性[1]。 S1R agonist 2 (24 h) 在 SHSY5Y 细胞中浓度为 1 μM 时对 Rotenone (HY-B1756) 诱导的细胞损伤有显著的抑制作用[1]。 S1R agonist 2 (0.1-5 μM; 24 h) 在 SHSY5Y 细胞中对 NMDA 刺激有神经保护作用[1]。 S1R agonist 2 (0-10 μM; 24-72 h) 对 A549、LoVo 和 Panc-1 细胞无细胞毒性[1]。 |
| In Vivo | S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) 在 10 μM 浓度下不诱导胚胎死亡 (100%存活胚胎)，但在最高剂量 (50 μM) 下诱导所有胚胎死亡[1]。 |
| References |
| Molecular Formula | C21H27NO |
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| Molecular Weight | 309.45 |